Publications [#339782] of Amanda Hargrove

Journal Articles

  1. Patwardhan, NN; Cai, Z; Newson, CN; Hargrove, AE, "Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA.", Organic & biomolecular chemistryFebruary,, 2019, 17(7), 1778-1786 [doi].
    (last updated on 2024/04/25)

    Abstract:
    A prominent hurdle in developing small molecule probes against RNA is the relative scarcity of general screening methods. In this study, we demonstrate the application of a fluorescent peptide displacement assay to screen small molecule probes against four different RNA targets. The designed experimental protocol combined with statistical analysis provides a fast and convenient method to simultaneously evaluate small molecule libraries against different RNA targets and classify them based on affinity and selectivity patterns.