Publications [#233207] of Andrew T. McPhail

Journal Articles

  1. Han, S; Hamel, E; Bastow, KF; McPhail, AT; Brossi, A; Lee, K-H, "Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.", Bioorganic & medicinal chemistry lettersOctober,, 2002, 12(20), 2851-2853 [Gateway.cgi], [doi].
    (last updated on 2026/01/21)

    Abstract:
    N-Acetylcolchinol methyl ether 1 served as the starting material to prepare the chloroacetamide (3) and epoxide (5) analogues. Both 3 and 5 were potent inhibitors of tubulin polymerization in vitro. Compound 3 was also 4-fold more cytotoxic than colchicine against the 1A9 tumor cell line and showed a unique cross-resistance profile.