Publications [#233215] of Andrew T. McPhail

Journal Articles

  1. Draper, RW; Hu, B; McPhail, AT; Puar, MS; Vater, EJ; Weber, L, "Unusual Hyroxyl-γ-sultone Byproducts of Steroid 21-Methanesulfonylation. An Efficient Synthesis of Mometasone 17-Furoate (Sch 32088)", Tetrahedron, 1999, 55(11), 3355-3364, Elsevier BV [doi].
    (last updated on 2026/01/21)

    Abstract:
    An efficient two stage synthesis of the steroid anti-inflammatory agent mometasone 17-furoate (Sch 32088) 4 from 17α,21-dihydroxy-16α-methyl- 9β,11β-oxidopregna-1,4-diene-3,20-dione 6 is described and the structures of unusual δ-hydroxy-γ-sultone byproducts of 4-dimethylaminopyridine catalyzed methanesulfonylation of 21-hydroxy-20-ketosteroids are deduced.