Publications [#233222] of Andrew T. McPhail

Journal Articles

  1. Afonso, A; Puar, MS; Kelly, J; McPhail, AT, "Synthesis of a C11 spirocyclopropyl derivative of 8-chloro-6,11- dihydro-5h-benzo[5,6]cyclohepta[1,2b]pyridine", Tetrahedron LettersOctober,, 1998, 39(42), 7657-7660, Elsevier BV [Gateway.cgi], [doi].
    (last updated on 2026/01/21)

    Abstract:
    The carbanion derived from 8,11-dichloro-6,11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b] pyridine (3) reacts with methyl acrylate to form the C11 spirocyclopropane carboxylic acid methyl ester 6. Compound 6 was converted in five steps to the N-methyl 2'-ethylamino spirocyclopropane 2 (R=H) which was required for a structure-activity study based on the lead Farnesyl Protein Transferase inhibitor 1.