Publications [#233244] of Andrew T. McPhail

Journal Articles

  1. McKittrick, BA; Ma, K; Dugar, S; Clader, JW; Davis, H; Czarniecki, M; McPhail, AT, "Stereoselective synthesis and biological activity of cis azetidinones as cholesterol absorption inhibitors", Bioorganic and Medicinal Chemistry LettersAugust,, 1996, 6(16), 1947-1950, Elsevier BV [Gateway.cgi], [doi].
    (last updated on 2026/01/21)

    Abstract:
    The C-3 sidechain of azetidinones related to SCH 48461 was modified by introducing a hydroxyl group at the 1' position. This led to the discovery of the cis azetidinone 2c, which had improved CAI activity. Compound 2c was prepared using a selective reduction and silane mediated debromination to control the relative stereochemistry of the three centers.