Publications [#233245] of Andrew T. McPhail

Journal Articles

  1. Blythin, DJ; Kuo, SC; Shue, HJ; McPhail, AT; Chapman, RW; Kreutner, W; Rizzo, C; She, HS; West, R, "Substituted Morpholine-2S-acetic Acid Derivatives: SCH 50911 and Related Compounds as Novel GABAB Antagonists", Bioorg. Med. Chem. Lett., 1996, 6(13), 1529-1534, Elsevier BV [Gateway.cgi], [doi].
    (last updated on 2026/01/21)

    Abstract:
    The synthesis and GABA(B) antagonist activity of a series of substituted morpholine-2-acetic acid derivatives is described. Resolution of the lead compound from the series produces one active and one inactive enantiomer. X- ray analysis of a halogenated derivative (25) of the active enantiomer Sch 50911 (23) shows that it possesses the 2S configuration.