Publications [#233266] of Andrew T. McPhail

Journal Articles

  1. Wall, ME; Wani, MC; Fullas, F; Oswald, JB; Brown, DM; Santisuk, T; Reutrakul, V; McPhail, AT; Farnsworth, NR; Pezzuto, JM, "Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.", Journal of medicinal chemistryMay,, 1994, 37(10), 1465-1470 [Gateway.cgi], [doi].
    (last updated on 2026/01/21)

    Abstract:
    Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.