Publications [#233269] of Andrew T. McPhail

Journal Articles

  1. Chen, CH; Yang, LM; Lee, TTY; Shen, YC; Zhang, DC; Pan, DJ; McPhail, AT; McPhail, DR; Liu, SY; Li, DH; Cheng, YC; Lee, KH, "Antitumor Agents, CLI. Bis(helenalinyl)Glutarate and Bis(isoalantodiol-B)-Glutarate, Potent Inhibitors of Human DNA Topoisomerase II", Bioorg. Med. Chem., 1994, 2(2), 137-145 [doi].
    (last updated on 2026/01/21)

    Abstract:
    Evaluation of a number of cytotoxic antitumor sesquiterpene lactones and their derivatives has led to the discovery of bis(helenalinyl)glutarate (4) and bis(isoalantodiol-B)glutarate (10) as potent inhibitors of human-derived topoisomerase II. Unlike etoposide, which inhibits by preventing the DNA rejoining process, compounds 4 and 10 inhibit topoisomerase II without causing DNA breakage. The structure-activity relationships of 4, 10, and related compounds are discussed.