Publications [#233301] of Andrew T. McPhail

Journal Articles

  1. El Feraly, FS; Al Yahya, MA; Orabi, KY; McPhail, DR; McPhail, AT, "A New Method for the Preparation of Arteether and Its C-9 Epimer", J. Nat. Prod., 1992, 55(7), 878-883 [doi].
    (last updated on 2026/01/21)

    Abstract:
    Arteether [4] was obtained by treating anhydrodihydroartemisinin [3] with absolute EtOH in the presence of p-toluenesulfonic acid as a catalyst. 9-epi-Arteether [6] was obtained as the minor product. The use of CH2Cl2 as a solvent yielded the latter as the major product. Its structure and absolute stereochemistry were unambiguously established from its spectral data and by X-ray crystallographic analysis. This procedure permitted the preparation of C-9 deuterated arteether [5], which may be needed for metabolic studies. © 1992, American Chemical Society. All rights reserved.