Publications [#233305] of Andrew T. McPhail

Journal Articles

  1. Chen, K; Shi, Q; Kashiwada, Y; Zhang, DC; Hy, CQ; Jin, JQ; Nozaki, H; Kilkuskie, RE; Tramontano, E; Cheng, YC; McPhail, DR; McPhail, AT; Lee, KH, "Anti-Acids Agents, 6. Salaspermic Acid, an Anti-HIV Principle from Tripterygium Wilfordii, and the Structure Activity Correlation with Its Related Compounds", J. Nat. Prod., 1992, 55(3), 340-346 [doi].
    (last updated on 2026/01/21)

    Abstract:
    Salaspermic acid [1], an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time. The structure of 1 derived from spectral data was established unequivocally by an X-ray analysis of crystals of the monohydrate. A structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity.