Publications [#233400] of Andrew T. McPhail

Journal Articles

  1. Jung, M; ElSohly, HN; Croom, EM; McPhail, AT; McPhail, DR, "Practical Conversion of Artemisinic Acid into Desoxyartemisinin", Journal of Organic ChemistryJanuary,, 1986, 51(26), 5417-5419, American Chemical Society (ACS) [Gateway.cgi], [doi].
    (last updated on 2026/01/21)

    Abstract:
    Artemisinin (Qinghaosu, 2) isolated from Artemisia annua has recently been used in China as a new type of antimalarial drug with rapid action and low toxicity against chloroquine-resistant malaria. Artemisinin is a novel sesquiterpene lactone bearing an unusual cyclic peroxide function. The combination of an interesting biological activity, a novel chemical structure, and a low yield from natural sources prompted us to search for a new synthesis of artemisinin and related compounds. Although interesting syntheses of artemisinin and desoxyartemisinin were reported recently, these complex syntheses do not provide feasible methods for large-scale production. © 1986, American Chemical Society. All rights reserved.