Publications [#233611] of Andrew T. McPhail

Journal Articles

  1. Coggon, P; McPhail, AT; Roe, AM, "Conformation of Xylocholine", Nature, 1969, 224(5225), 1200-1201, Springer Nature [doi].
    (last updated on 2026/01/21)

    Abstract:
    THE biological activity of quaternary aryloxyethylammonium salts is critically dependent on the nature and position of the substituents in the aromatic ring 1-3. Thus choline phenyl ether bromide is a potent nicotine-like ganglion stimulant 2,4, whereas its 2,6-dimethyl analogue (xylocholine) is devoid of ganglion stimulant activity 5 but was the first compound to exhibit adrenergic neurone blocking activity 6-9. Xylocholine also has muscarine-like properties 6-9. © 1969 Nature Publishing Group.