Publications [#233666] of Andrew T. McPhail

Journal Articles

  1. Hegde, VR; Puar, MS; Dai, P; Patel, M; Gullo, VP; Das, PR; Bond, RW; McPhail, AT, "A novel microbial metabolite, activator of low density lipoprotein receptor promoter", Tetrahedron LettersFebruary,, 2000, 41(9), 1351-1354, Elsevier BV [Gateway.cgi], [doi].
    (last updated on 2026/01/21)

    Abstract:
    The organic extract of the fermentation broth of a Micromonospora microorganism was found to contain SCH 351448 (1), the monosodium salt of a macrocyclic dilactone containing two identical diacids. The structure and relative stereochemistry were established by single-crystal X-ray analysis. SCH 351448 is a novel ionophoric compound and is a weak activator of low density lipoprotein receptor (LDL-R) promoter with an IC50 of 25 μM. (C) 2000 Elsevier Science Ltd.