Publications [#233889] of Barbara R. Shaw

Journal Articles

  1. Lin, J; Shaw, BR, "Synthesis of new classes of boron-containing nucleotides.", Nucleosides, nucleotides & nucleic acidsApril,, 2001, 20(4-7), 587-596 [11563076], [doi].
    (last updated on 2024/04/19)

    Abstract:
    Four different types of boron-modified nucleotides are reported: P-boranophosphorothioates, P-cyanoboranophosphates, P-boranomethylphosphonates, and P3'-N5'-boranophosphoramidates. Synthesis of dinucleoside borano-phosphorothioates and nucleoside P-borano-P-thiomonophosphates via a lithium sulfide method is described. The Li2S method also provides an alternative way to synthesize phosphorothioates through a dinitrophenyl P(V) phosphotriester precursor. The mechanism of Li2S substitution was investigated.