Publications [#233164] of Dewey G. McCafferty

Journal Articles

  1. Kudryavtsev, KV; Bentley, ML; McCafferty, DG, "Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform.", Bioorganic & medicinal chemistryApril,, 2009, 17(7), 2886-2893 [doi].
    (last updated on 2024/07/16)

    Abstract:
    cis-5-Phenyl prolinates with electrophilic substituents at the fourth position of a pyrrolidine ring were synthesized by 1,3-dipolar cycloaddition of arylimino esters with divinyl sulfone and acrylonitrile. 4-Vinylsulfonyl 5-phenyl prolinates inhibit Staphylococcus aureus sortase SrtA irreversibly by modification of the enzyme Cys184 and could be used as hits for the development of antibacterials and antivirulence agents.