Publications [#232562] of Michael C. Fitzgerald

Journal Articles

  1. Qian, X; Morís-Varas, F; Fitzgerald, MC; Wong, CH, "C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases.", Bioorganic & medicinal chemistryDecember,, 1996, 4(12), 2055-2069 [doi].
    (last updated on 2026/01/17)

    Abstract:
    C2-Symmetrical tetrahydroxyazepanes were synthesized as inhibitors for glycosidases. Tetrahydroxyazepane 1 is a non-specific inhibitor of various glycosidases, while compounds 2, 3 and 4 specifically inhibit beta-N-acetylglucosaminidase, beta-glucosidase, and alpha-fucosidase, respectively, with Ki in the micromolar range. Compound 1 is not an inhibitor of HIV/FIV proteases, but its 3,6-difluorobenzyl derivatives are moderate inhibitors of both enzymes.