Publications [#330258] of Michael J. Therien

Papers Published

  1. Gauthier, JY; Henien, T; Lo, L; Thérien, M; Young, RN, "A novel and efficient method for the preparation of asymmetric dithioacetals", Tetrahedron LettersJanuary,, 1988, 29(51), 6729-6732, Elsevier BV [doi].
    (last updated on 2026/01/19)

    Abstract:
    Aldehydes and ketones react with one equivalent each of thiols and thiolacetic acid under acid catalysis to yield almost exclusively the mixed alkylthio-(or arylthio-) acylthioacetals. Reaction of the mixed thioacetal with a nucleophile (such as NaOMe) liberates the thiolate anion which can be trapped with a variety of electrophiles to provide asymmetric dithioacetals in high yields. © 1988.