Publications [#346083] of Matthew L Becker
Journal Articles
- Zheng, J; Liu, K; Reneker, DH; Becker, ML, "Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition.", Journal of the American Chemical SocietyOctober,, 2012, 134(41), 17274-17277 [doi].
(last updated on 2024/11/19)Abstract:
A primary amine-derivatized 4-dibenzocyclooctynol (DIBO) was used to initiate the ring-opening polymerization of poly(γ-benzyl-L-glutamate) (DIBO-PBLG). This initiator yields well-defined PBLG polymers functionalized with DIBO at the chain termini. The DIBO end group further survives an electrospinning process that yields nanofibers that were then derivatized post-assembly with azide-functionalized gold nanoparticles. The availability of DIBO on the surface of the fibers is substantiated by fluorescence, SEM, and TEM measurements. Post-assembly functionalization of nanofiber constructs with bioactive groups can be facilitated easily using this process.