Publications [#346089] of Matthew L Becker

Journal Articles

  1. Yu, J; Becker, ML; Carri, GA, "The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces.", Langmuir : the ACS journal of surfaces and colloidsJanuary,, 2012, 28(2), 1408-1417 [doi].
    (last updated on 2024/11/19)

    Abstract:
    We present a molecular dynamics study of the binding process of peptide A3 (AYSSGAPPMPPF) and other similar peptides onto gold surfaces, and identify the functions of many amino acids. Our results provide a clear picture of the separate regimes present in the binding process: diffusion, anchoring, crawling and binding. Moreover, we explored the roles of individual residues. We found that tyrosine, methionine, and phenylalanine are strong binding residues; serine serves as an effective anchoring residue; proline acts as a dynamic anchoring point, while glycine and alanine give flexibility to the peptide backbone. We then show that our findings apply to unrelated phage-derived sequences that have been reported recently to facilitate AuNP synthesis. This new knowledge may aid in the design of new peptides for the synthesis of gold nanostructures with novel morphologies.