Publications [#234261] of Qiu Wang
Journal Articles
- McDonald, SL; Wang, Q, "Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates.", Chemical communications (Cambridge, England)March,, 2014, 50(19), 2535-2538 [doi].
(last updated on 2024/11/19)Abstract:
Selective α-amination and α-acylation of esters and amides have been developed, employing O-acylhydroxylamines as a dually reactive aminating and acylating reagent. Treatment of zinc enolates with O-acylhydroxylamines provides solely 1,3-dicarbonyl compounds under mild conditions. Introduction of a copper catalyst into the system shifts the reactivity entirely, yielding α-amination products exclusively.