Publications [#325594] of Qiu Wang
Journal Articles
- Ortiz, GX; Hemric, BN; Wang, Q, "Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.", Organic lettersMarch,, 2017, 19(6), 1314-1317 [doi].
(last updated on 2024/11/19)Abstract:
Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl2. Interestingly, analogous reactions in the absence of ZnCl2 resulted in the formation of indole aminal products.