Publications [#359840] of Qiu Wang
Journal Articles
- Bae, J; Zhang, G; Park, H; Warren, WS; Wang, Q, "15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents.", Chemical scienceNovember,, 2021, 12(42), 14309-14315 [doi].
(last updated on 2024/11/19)Abstract:
Azide moieties, unique linear species containing three nitrogen atoms, represent an attractive class of molecular tag for hyperpolarized magnetic resonance imaging (HP-MRI). Here we demonstrate (15N)3-azide-containing molecules exhibit long-lasting hyperpolarization lifetimes up to 9.8 min at 1 T with remarkably high polarization levels up to 11.6% in water, thus establishing (15N)3-azide as a powerful spin storage for hyperpolarization. A single (15N)-labeled azide has also been examined as an effective alternative tag with long-lived hyperpolarization. A variety of biologically important molecules are studied in this work, including choline, glucose, amino acid, and drug derivatives, demonstrating great potential of 15N-labeled azides as universal hyperpolarized tags for nuclear magnetic resonance imaging applications.