Publications [#231797] of Steven W. Baldwin
Journal Articles
- Mao, Z; Baldwin, SW, "New spirocyclic oxindole synthesis based on a hetero Claisen rearrangement.", Organic lettersJuly,, 2004, 6(14), 2425-2428 [15228295], [doi].
(last updated on 2024/03/28)Abstract:
[reaction: see text] A new method for preparing spirocyclic oxindoles is presented. Featuring a [3,3]-sigmatropic enolate rearrangement, the three-step process converts carboxylic acid starting materials to oxidnole products in overall yields of 52-76%. The enolate rearrangement step occurs at -78 degrees C and provides easy access to oxindole products that have previously been difficult to prepare.