Publications [#231842] of Steven W. Baldwin

Journal Articles

  1. Baldwin, SW; Chen, P; Nikolic, N; Weinseimer, DC, "A solution to the cyclic aldol problem", Organic lettersMay,, 2000, 2(9), 1193-1196 [10810705], [doi].
    (last updated on 2024/04/24)

    Abstract:
    [formula: see text] A protocol for achieving stereoselective aldol reactions with cyclic ketones is presented. In terms of yield, the process is particularly effective when a quaternary center at the alpha-carbon of the beta-hydroxy ketone product is created. The stereochemical outcome, anti or syn, is achieved by the Lewis acid-mediated ring expansion of stereochemically homogeneous epoxides in a reaction related to the pinacol rearrangement.