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| Publications [#205009] of Lesley H Curtis
Papers Published
- KK Patton, EJ Benjamin, A Kosheleva, LH Curtis, MM Glymour, Early-life antecedents of atrial fibrillation: place of birth and atrial fibrillation-related mortality.,
Annals of epidemiology, vol. 21 no. 10
(October, 2011),
pp. 732-8, ISSN 1873-2585 [doi]
(last updated on 2012/05/01)
Abstract:
OBJECTIVE: Recent evidence suggests early-life factors correlate with atrial fibrillation (AF). We hypothesized that AF-related mortality, similar to stroke mortality, is elevated for individuals born in the southeastern United States. METHODS: We estimated 3-year (1999-2001) average AF-related mortality rates by using U.S. vital statistics for 55- to 89-year-old white (136,573 AF-related deaths) and black subjects (8,288 AF-related deaths). We estimated age- and sex-adjusted odds of AF-related (contributing cause) mortality associated with birth state, and birth within the U.S. stroke belt (SB), stratified by race. SB results were replicated with the use of 1989-1991 data. RESULTS: Among black subjects, four contiguous birth states were associated with statistically significant odds ratios ≥ 1.25 compared with the national average AF-related mortality. The four highest-risk birth states for blacks also predicted elevated AF-related mortality among white subjects, but patterns were attenuated. The odds ratio for AF-related mortality associated with SB birth was 1.19 (confidence interval 1.13-1.25) for black and 1.09 (CI 1.07-1.12) for white subjects when we adjusted for SB adult residence. CONCLUSIONS: Place of birth predicted AF-related mortality, after we adjusted for place of adult residence. The association of AF-related mortality and SB birth parallels that of other cardiovascular diseases and may likewise indicate an importance of early life factors in the development of AF.
Keywords:
African Americans • Aged • Aged, 80 and over • Atrial Fibrillation • European Continental Ancestry Group • Female • Geography • Humans • Male • Middle Aged • Residence Characteristics • Risk Factors • Southeastern United States • epidemiology • ethnology* • mortality* • statistics & numerical data • statistics & numerical data*
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