Papers Published
- Lichtman, JW; Magrassi, L; Purves, D, Visualization of neuromuscular junctions over periods of several months in living mice.,
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 7 no. 4
(April, 1987),
pp. 1215-1222 [doi].
(last updated on 2023/06/01)
Abstract: Identified neuromuscular junctions were followed in the sternomastoid muscle of living mice for several months by repeated staining with the fluorescent dye 4-(4-diethylaminostyryl)-N-methylpyridinium iodide (4-Di-2-ASP; Magrassi et al., 1987). Overall terminal growth occurred at many endplates; however, the branching pattern of presynaptic arbors was largely unchanged, even after several months. The absence of significant remodeling over time was not a result of dye-staining, since sprouting was readily induced at residual motor endings by partial denervation. We conclude that--apart from overall growth--most neuromuscular junctions in the adult mouse are stable over intervals that represent a significant fraction of the animal's lifetime.
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