Mark Oldham, Professor of Radiation Oncology
Office Location: 04214 Duke South Clinics, Duke South Clinics, Durham, NC 27710
Email Address: mark.oldham@duke.edu
Education:
Ph.D., Newcastle University (United Kingdom), 1991
Teaching (Spring 2025):
- Medphy 520.01, Radiation therapy physics
Synopsis
- Hock plaza 1034, TuTh 10:05 AM-11:20 AM
Representative Publications
(More Publications)
- Wang, Z; Thomas, A; Newton, J; Ibbott, G; Deasy, J; Oldham, M, Dose Verification of Stereotactic Radiosurgery Treatment for Trigeminal Neuralgia with Presage 3D Dosimetry System.,
J Phys Conf Ser, vol. 250 no. 1
(December, 2010) [doi] [abs].
- Oldham, M; Clift, C; Thomas, A; Farfan, E; Foley, T; Jannik, T; Adamovics, J; Holmes, C; Stanley, S, Initial experience with optical-CT scanning of RadBall Dosimeters.,
J Phys Conf Ser, vol. 250 no. 1
(December, 2010) [doi] [abs].
- Grant, RL; Crowder, ML; Ibbott, GS; Simon, J; Frank, RK; Rogers, J; Loy, HM; Adamovics, J; Newton, J; Oldham, M; Stearns, S; Wendt, RE, Three-Dimensional Dosimetry of a Beta-Emitting Radionuclide Using PRESAGE Dosimeters.,
J Phys Conf Ser, vol. 250 no. 1
(December, 2010) [doi] [abs].
- Thomas, A; Bowsher, J; Roper, J; Oliver, T; Dewhirst, M; Oldham, M, A comprehensive method for optical-emission computed tomography.,
Phys Med Biol, vol. 55 no. 14
(July, 2010),
pp. 3947-3957 [doi] [abs].
- Brady, SL; Brown, WE; Clift, CG; Yoo, S; Oldham, M, Investigation into the feasibility of using PRESAGE/optical-CT dosimetry for the verification of gating treatments.,
Phys Med Biol, vol. 55 no. 8
(April, 2010),
pp. 2187-2201 [doi] [abs].
- Baldock, C; De Deene, Y; Doran, S; Ibbott, G; Jirasek, A; Lepage, M; McAuley, KB; Oldham, M; Schreiner, LJ, Polymer gel dosimetry.,
Phys Med Biol, vol. 55 no. 5
(March, 2010),
pp. R1-63 [doi] [abs].
- Clift, C; Thomas, A; Adamovics, J; Chang, Z; Das, I; Oldham, M, Toward acquiring comprehensive radiosurgery field commissioning data using the PRESAGE/optical-CT 3D dosimetry system.,
Phys Med Biol, vol. 55 no. 5
(March, 2010),
pp. 1279-1293 [doi] [abs].
- Pierquet, M; Thomas, A; Adamovics, J; Oldham, M, An investigation into a new re-useable 3D radiochromic dosimetry material, Presage.,
J Phys Conf Ser, vol. 250 no. 1
(January, 2010),
pp. 1-4 [doi] [abs].
- Thomas, A; Oldham, M, Fast, large field-of-view, telecentric optical-CT scanning system for 3D radiochromic dosimetry.,
J Phys Conf Ser, vol. 250 no. 1
(January, 2010),
pp. 1-5 [doi] [abs].
- Stunja, L; Thomas, A; Adamovics, J; Deasy, J; Oldham, M, A 'quad-phantom' film dosimeter for use as a multi-planar verification tool for PRESAGE/optical-CT.,
J Phys Conf Ser, vol. 250 no. 1
(2010),
pp. 12097 [doi] [abs].
- Thomas, A; Pierquet, M; Oldham, M, Achieving accurate radiochromic optical-CT imaging when using a polychromatic light source.,
J Phys Conf Ser, vol. 250 no. 12045
(2010),
pp. 210-214 [doi] [abs].
- Newton, J; Thomas, A; Ibbott, G; Oldham, M, Preliminary commissioning investigations with the DMOS-RPC optical-CT Scanner.,
J Phys Conf Ser, vol. 250 no. 1
(2010),
pp. 12078 [doi] [abs].
- Sakhalkar, H; Sterling, D; Adamovics, J; Ibbott, G; Oldham, M, Investigation of the feasibility of relative 3D dosimetry in the Radiologic Physics Center Head and Neck IMRT phantom using presage/optical-CT.,
Med Phys, vol. 36 no. 7
(July, 2009),
pp. 3371-3377 [doi] [abs].
- Sakhalkar, HS; Adamovics, J; Ibbott, G; Oldham, M, A comprehensive evaluation of the PRESAGE/optical-CT 3D dosimetry system.,
Med Phys, vol. 36 no. 1
(January, 2009),
pp. 71-82 [doi] [abs].
- Sakhalkar, HS; Adamovics, J; Ibbott, G; Oldham, M, An Investigation into the Robustness of Optical-CT Dosimetry of a Radiochromic Dosimeter Compatible with the RPC Head-and-Neck Phantom.,
J Phys Conf Ser, vol. 164 no. 1
(January, 2009),
pp. 12059 [doi] [abs].
- Sakhalkar, H; Sterling, D; Adamovics, J; Ibbott, G; Oldham, M, Investigating the Feasibility of 3D Dosimetry in the RPC IMRT H&N Phantom.,
J Phys Conf Ser, vol. 164 no. 2009
(2009),
pp. 12058 [doi] [abs].
- Kim, E; Bowsher, J; Thomas, AS; Sakhalkar, H; Dewhirst, M; Oldham, M, Improving the quantitative accuracy of optical-emission computed tomography by incorporating an attenuation correction: application to HIF1 imaging.,
Phys Med Biol, vol. 53 no. 19
(October, 2008),
pp. 5371-5383 [doi] [abs].
- Oldham, M; Sakhalkar, H; Oliver, T; Allan Johnson, G; Dewhirst, M, Optical clearing of unsectioned specimens for three-dimensional imaging via optical transmission and emission tomography.,
J Biomed Opt, vol. 13 no. 2
(2008),
pp. 021113 [doi] [abs].
- Oldham, M; Sakhalkar, H; Guo, P; Adamovics, J, An investigation of the accuracy of an IMRT dose distribution using two- and three-dimensional dosimetry techniques.,
Med Phys, vol. 35 no. 5
(May, 2008),
pp. 2072-2080 [doi] [abs].
- Sakhalkar, HS; Oldham, M, Fast, high-resolution 3D dosimetry utilizing a novel optical-CT scanner incorporating tertiary telecentric collimation.,
Med Phys, vol. 35 no. 1
(January, 2008),
pp. 101-111 [doi] [abs].
- Godfrey, DJ; Ren, L; Yan, H; Wu, Q; Yoo, S; Oldham, M; Yin, FF, Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS).,
Med Phys, vol. 34 no. 8
(August, 2007),
pp. 3374-3384 [doi] [abs].
- Oldham, M; Sakhalkar, H; Wang, YM; Guo, P; Oliver, T; Bentley, R; Vujaskovic, Z; Dewhirst, M, Three-dimensional imaging of whole rodent organs using optical computed and emission tomography.,
J Biomed Opt, vol. 12 no. 1
(2007),
pp. 014009 [doi] [abs].
- Sakhalkar, HS; Dewhirst, M; Oliver, T; Cao, Y; Oldham, M, Functional imaging in bulk tissue specimens using optical emission tomography: fluorescence preservation during optical clearing.,
Phys Med Biol, vol. 52 no. 8
(April, 2007),
pp. 2035-2054 [doi] [abs].
- Oldham, M; Sakhalkar, H; Guo, P, A dual-purpose CCD based micro-optical-CT scanning system.,
J Phys Conf Ser, vol. 56 no. 1
(December, 2006),
pp. 199-202 [doi] .
- Guo, P; Adamovics, J; Oldham, M, Quality assurance in 3D dosimetry by optical-CT.,
J Phys Conf Ser, vol. 56 no. 1
(December, 2006),
pp. 191-194 [doi] .
- Guo, P; Adamovics, J; Oldham, M, A practical three-dimensional dosimetry system for radiation therapy.,
Med Phys, vol. 33 no. 10
(October, 2006),
pp. 3962-3972 [doi] [abs].
- Oldham, M; Sakhalkar, H; Oliver, T; Wang, YM; Kirpatrick, J; Cao, Y; Badea, C; Johnson, GA; Dewhirst, M, Three-dimensional imaging of xenograft tumors using optical computed and emission tomography.,
Med Phys, vol. 33 no. 9
(September, 2006),
pp. 3193-3202 [doi] [abs].
- Guo, PY; Adamovics, JA; Oldham, M, Characterization of a new radiochromic three-dimensional dosimeter.,
Med Phys, vol. 33 no. 5
(May, 2006),
pp. 1338-1345 [doi] [abs].
- Godfrey, DJ; Yin, F-F; Oldham, M; Yoo, S; Willett, C, Digital tomosynthesis with an on-board kilovoltage imaging device.,
Int J Radiat Oncol Biol Phys, vol. 65 no. 1
(May, 2006),
pp. 8-15 [doi] [abs].
- Yin, F-F; Das, S; Kirkpatrick, J; Oldham, M; Wang, Z; Zhou, S-M, Physics and imaging for targeting of oligometastases.,
Semin Radiat Oncol, vol. 16 no. 2
(April, 2006),
pp. 85-101 [doi] [abs].
- Oldham, M, 3D dosimetry by optical-CT scanning.,
J Phys Conf Ser, vol. 56
(2006),
pp. 58-71 [doi] [abs].
- Oldham, M; Guo, P; Gluckman, G; Adamovics, J, IMRT verification using a radiochromic/optical-CT dosimetry system.,
J Phys Conf Ser, vol. 56
(2006),
pp. 221-224 [doi] .
- Oldham, M; Guo, P; Adamovics, J; Sakhalkar, H; Wang, Z; Yin, F, Towards four dimensional (4D) dosimetry for radiation-therapy.,
J Phys Conf Ser, vol. 56
(2006),
pp. 225-227 [doi] .
- Oldham, M; Létourneau, D; Watt, L; Hugo, G; Yan, D; Lockman, D; Kim, LH; Chen, PY; Martinez, A; Wong, JW, Cone-beam-CT guided radiation therapy: A model for on-line application.,
Radiother Oncol, vol. 75 no. 3
(June, 2005),
pp. 271-278 [doi] [abs].
- Létourneau, D; Wong, JW; Oldham, M; Gulam, M; Watt, L; Jaffray, DA; Siewerdsen, JH; Martinez, AA, Cone-beam-CT guided radiation therapy: technical implementation.,
Radiother Oncol, vol. 75 no. 3
(June, 2005),
pp. 279-286 [doi] [abs].
- Oldham, M; Kim, L; Hugo, G, Optical-CT imaging of complex 3D dose distributions.,
J Phys Conf Ser, vol. 5745
(April, 2005),
pp. 138-146 [doi] [abs].
- Das, SK; Baydush, AH; Zhou, S; Miften, M; Yu, X; Craciunescu, O; Oldham, M; Light, K; Wong, T; Blazing, M; Borges-Neto, S; Dewhirst, MW; Marks, LB, Predicting radiotherapy-induced cardiac perfusion defects.,
Med Phys, vol. 32 no. 1
(January, 2005),
pp. 19-27 [doi] [abs].
- Oldham, M; Kim, L, Optical-CT gel-dosimetry. II: Optical artifacts and geometrical distortion.,
Med Phys, vol. 31 no. 5
(May, 2004),
pp. 1093-1104 [doi] [abs].
- Létourneau, D; Gulam, M; Yan, D; Oldham, M; Wong, JW, Evaluation of a 2D diode array for IMRT quality assurance.,
Radiother Oncol, vol. 70 no. 2
(February, 2004),
pp. 199-206 [doi] [abs].
- Oldham, M, Optical-CT scanning of polymer gels.,
J Phys Conf Ser, vol. 3
(2004),
pp. 122-135 [doi] [abs].
- Oldham, M; Siewerdsen, JH; Kumar, S; Wong, J; Jaffray, DA, Optical-CT gel-dosimetry I: basic investigations.,
Med Phys, vol. 30 no. 4
(April, 2003),
pp. 623-634 [doi] [abs].
- Oldham, M; Sapareto, SA; Li, XA; Allen, J; Sutlief, S; Wong, OC; Wong, JW, Practical aspects of in situ 16O (gamma,n) 15O activation using a conventional medical accelerator for the purpose of perfusion imaging.,
Med Phys, vol. 28 no. 8
(August, 2001),
pp. 1669-1678 [doi] [abs].
- Oldham, M; Siewerdsen, JH; Shetty, A; Jaffray, DA, High resolution gel-dosimetry by optical-CT and MR scanning.,
Med Phys, vol. 28 no. 7
(July, 2001),
pp. 1436-1445 [doi] [abs].
- McJury, M; Oldham, M; Cosgrove, VP; Murphy, PS; Doran, S; Leach, MO; Webb, S, Radiation dosimetry using polymer gels: methods and applications.,
Br J Radiol, vol. 73 no. 873
(September, 2000),
pp. 919-929 [doi] [abs].
- Low, DA; Markman, J; Dempsey, JF; Mutic, S; Oldham, M; Venkatesan, R; Haacke, EM; Purdy, JA, Noise in polymer gel measurements using MRI.,
Med Phys, vol. 27 no. 8
(August, 2000),
pp. 1814-1817 [doi] [abs].
- Baustert, IC; Oldham, M; Smith, TA; Hayes, C; Webb, S; Leach, MO, Optimized MR imaging for polyacrylamide gel dosimetry.,
Phys Med Biol, vol. 45 no. 4
(April, 2000),
pp. 847-858 [doi] [abs].
- McJury, M; Tapper, PD; Cosgrove, VP; Murphy, PS; Griffin, S; Leach, MO; Webb, S; Oldham, M, Experimental 3D dosimetry around a high-dose-rate clinical 192Ir source using a polyacrylamide gel (PAG) dosimeter.,
Phys Med Biol, vol. 44 no. 10
(October, 1999),
pp. 2431-2444 [doi] [abs].
- Rowbottom, CG; Webb, S; Oldham, M, Beam-orientation customization using an artificial neural network.,
Phys Med Biol, vol. 44 no. 9
(September, 1999),
pp. 2251-2262 [doi] [abs].
- Khoo, VS; Oldham, M; Adams, EJ; Bedford, JL; Webb, S; Brada, M, Comparison of intensity-modulated tomotherapy with stereotactically guided conformal radiotherapy for brain tumors.,
Int J Radiat Oncol Biol Phys, vol. 45 no. 2
(September, 1999),
pp. 415-425 [doi] [abs].
- McJury, M; Oldham, M; Leach, MO; Webb, S, Dynamics of polymerization in polyacrylamide gel (PAG) dosimeters: (I) ageing and long-term stability.,
Phys Med Biol, vol. 44 no. 8
(August, 1999),
pp. 1863-1873 [doi] [abs].
- Bedford, JL; Khoo, VS; Oldham, M; Dearnaley, DP; Webb, S, A comparison of coplanar four-field techniques for conformal radiotherapy of the prostate.,
Radiother Oncol, vol. 51 no. 3
(June, 1999),
pp. 225-235 [doi] [abs].
- Rowbottom, CG; Oldham, M; Webb, S, Constrained customization of non-coplanar beam orientations in radiotherapy of brain tumours.,
Phys Med Biol, vol. 44 no. 2
(February, 1999),
pp. 383-399 [doi] [abs].
- Rowbottom, CG; Webb, S; Oldham, M, Is it possible to optimize a radiotherapy treatment plan?,
Int J Radiat Oncol Biol Phys, vol. 43 no. 3
(February, 1999),
pp. 698-699 [doi] .
- Guzel, Z; Bedford, JL; Childs, PJ; Nahum, AE; Webb, S; Oldham, M; Tait, D, A comparison of conventional and conformal radiotherapy of the oesophagus: work in progress.,
Br J Radiol, vol. 71 no. 850
(October, 1998),
pp. 1076-1082 [doi] [abs].
- Oldham, M; McJury, M; Baustert, IB; Webb, S; Leach, MO, Improving calibration accuracy in gel dosimetry.,
Phys Med Biol, vol. 43 no. 10
(October, 1998),
pp. 2709-2720 [doi] [abs].
- Oldham, M; Khoo, VS; Rowbottom, CG; Bedford, JL; Webb, S, A case study comparing the relative benefit of optimizing beam weights, wedge angles, beam orientations and tomotherapy in stereotactic radiotherapy of the brain.,
Phys Med Biol, vol. 43 no. 8
(August, 1998),
pp. 2123-2146 [doi] [abs].
- Rowbottom, CG; Webb, S; Oldham, M, Improvements in prostate radiotherapy from the customization of beam directions.,
Med Phys, vol. 25 no. 7 Pt 1
(July, 1998),
pp. 1171-1179 [doi] [abs].
- Oldham, M; Baustert, I; Lord, C; Smith, TA; McJury, M; Warrington, AP; Leach, MO; Webb, S, An investigation into the dosimetry of a nine-field tomotherapy irradiation using BANG-gel dosimetry.,
Phys Med Biol, vol. 43 no. 5
(May, 1998),
pp. 1113-1132 [doi] [abs].
- Bedford, JL; Oldham, M; Hoess, A; Evans, PM; Shentall, GS; Webb, S, Methods for transferring patient and plan data between radiotherapy treatment planning systems,
British Journal of Radiology, vol. 70 no. JULY
(1997),
pp. 740-749 [doi] [abs].
- Oldham, M; Webb, S, Intensity-modulated radiotherapy by means of static tomotherapy: a planning and verification study.,
Med Phys, vol. 24 no. 6
(June, 1997),
pp. 827-836 [doi] [abs].
- Webb, S; Oldham, M, A method to study the characteristics of 3D dose distributions created by superposition of many intensity-modulated beams delivered via a slit aperture with multiple absorbing vanes.,
Phys Med Biol, vol. 41 no. 10
(October, 1996),
pp. 2135-2153 [doi] [abs].
- Oldham, M; Neal, AJ; Webb, S, The optimisation of wedge filters in radiotherapy of the prostate.,
Radiother Oncol, vol. 37 no. 3
(December, 1995),
pp. 209-220 [doi] [abs].
- Neal, AJ; Oldham, M; Dearnaley, DP, Comparison of treatment techniques for conformal radiotherapy of the prostate using dose-volume histograms and normal tissue complication probabilities.,
Radiother Oncol, vol. 37 no. 1
(October, 1995),
pp. 29-34 [doi] [abs].
- Oldham, M; Webb, S, The optimization and inherent limitations of 3D conformal radiotherapy treatment plans of the prostate.,
Br J Radiol, vol. 68 no. 812
(August, 1995),
pp. 882-893 [doi] [abs].
- Oldham, M; Neal, A; Webb, S, A comparison of conventional 'forward planning' with inverse planning for 3D conformal radiotherapy of the prostate.,
Radiother Oncol, vol. 35 no. 3
(June, 1995),
pp. 248-262 [doi] [abs].
Highlight:
Dr Oldham is the Director of the Duke Medical Physics MS/PhD Graduate Program, and Professor in the Department of Radiation Oncology, with a secondary appointment in the Physics Department at Duke.
Main current research interests include: FLASH radiation therapy, exploring FLASH mechanisms utilizing the Duke High Intensity Gamma Source (HIGS), a nuclear research accelerator on the Duke campus. Recent work selected for best in Physics at the annual AAPM meeting. Radiation and Immunotherapy utilizing mini-grids. Radiation Therapy Enhanced by Cherenkov photo-Activation (RECA) and Comprehensive 3D dosimetry.
Dr Oldham has patented and published on several novel radiation treatment techniques (including XPACT and RECA - Radiotherapy Enhanced by Cherenkov photo-Activation) with exiting potential to invoke systemic anti-cancer immunogenic response. A phase I clinical trial of XPACT is underway. The lab has pioneered novel pre-clinical treatment capabilities including mini-beam grids, and ultra-high-resolution IMRT. The lab has also developed novel optical imaging techniques for high-resolution 3D imaging of vascular networks and fluorescent gene expression in un-sectioned tissue samples.