Publications [#256734] of Kenneth C. Land

Papers Published

1. Yashin, AI; Wu, D; Arbeev, KG; Stallard, E; Land, KC; Ukraintseva, SV, How genes influence life span: the biodemography of human survival., Rejuvenation research, vol. 15 no. 4 (August, 2012), pp. 374-380 [22607627], [doi]
   (last updated on 2025/06/16)

   Abstract:
   

   Background

   In genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain unclear.

   Data and method

   A biodemographic analyses was done of genetic regulation of life span using data on low-significance longevity alleles selected in the earlier GWAS of the original Framingham cohort.

   Results

   Age-specific survival curves considered as functions of the number of longevity alleles exhibit regularities known in demography as "rectangularization" of survival curves. The presence of such pattern confirms observations from experimental studies that regulation of life span involves genes responsible for stress resistance.

   Conclusion

   Biodemographic analyses could provide important information about the properties of genes affecting phenotypic traits.