Faculty Database System- Arts & Sciences and Trinity College

Alvin L. Crumbliss, University Distinguished Service Professor Emeritus

Office Location:	2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Office Phone:	(919) 660-1540
Email Address:
Web Page:	http://sites.duke.edu/crumbliss/

Education:: Ph.D. Northwestern University 1968; B.A. Knox College 1964; A.B. with College Honors Knox College 1964

Research Interests:: Dr. Crumbliss is a coordination chemist who studies the function, reactivity and mobility of transition metals in biological systems. A major emphasis in his lab currently is investigations related to the biochemistry of iron. Through application of kinetic, spectroscopic and electrochemical techniques the Crumbliss group is investigating low molecular weight iron carriers (siderophores and synthetic siderophore mimics) and high molecular weight iron carriers (mammalian and bacterial transferrin proteins) with respect to their ability to mobilize and deposit iron at specific sites in a biological system. The structure/function role of iron in heme proteins, such as the hemoglobins and myoglobins, is under investigation. Synthetic materials for metal-specific chelation designed using principles learned from biology are under investigation.

Recent Publications (More Publications)

Crumbliss, AL; Banerjee, S, A perspective essay on the use of Ga³⁺ as a proxy for Fe³⁺ in bioinorganic model studies and its successful use for therapeutic purposes., Journal of Inorganic Biochemistry, vol. 219 (June, 2021), pp. 111411 [doi] [abs].
Ghio, AJ; Soukup, JM; Dailey, LA; Roggli, VL; Crumbliss, AL; Palmer, SM, Diacetyl exposure disrupts iron homeostasis in animals and cells., Inhal Toxicol, vol. 33 no. 6-8 (2021), pp. 268-274 [doi] [abs].
Ciferri, A; Crumbliss, AL, Supramolecular and Liquid Crystalline Contributions to the Assembly of Myofibril., Molecules (Basel, Switzerland), vol. 25 no. 4 (February, 2020), pp. E862 [doi] [abs].
Ciferri, A; Crumbliss, AL, A Supramolecular Polymerization Approach to the Growth of the Myofibril., Frontiers in Chemistry, vol. 7 (January, 2019), pp. 487 [doi] [abs].
Harrington, JM; Mysore, MM; Crumbliss, AL, The kinetics of dimethylhydroxypyridinone interactions with iron(iii) and the catalysis of iron(iii) ligand exchange reactions: implications for bacterial iron transport and combination chelation therapies., Dalton Transactions (Cambridge, England : 2003), vol. 47 no. 20 (May, 2018), pp. 6954-6964 [doi] [abs].