Publications [#280311] of David J. Brady
- McCain, ST; Gehm, ME; Wang, Y; Pitsianis, NP; Brady, DJ, Raman spectroscopy: Large-aperture raman spectroscopy for quantitative chemometrics,
Optics and Photonics News, vol. 17 no. 12
pp. 42, ISSN 1047-6938
(last updated on 2019/11/15)
The creation of an inexpensive, mechanically robust, large-aperture Raman spectrometry for quantitative chemometrics is presented. The traditional slit aperture is replaced with a large-aperture pattern of significant complexity, which converts the instrument into a computational sensor. A specific patter is chosen to have mathematical properties that optimized the performance of this processing step. The pattern is designed so that each column of the pattern acts as a virtual slit, measuring the spectrum at high resolution and combining its result with all the other columns to increase the number of collected photons. A data model is constructed, which use a standard partial least-squares algorithm by using measurements made on liquid tissue phantoms spiked with varying concentrations of ethanol. The successful quantitative measurements in a scattering medium represents a significant step on the path toward the eventual clinical application of Raman spectroscopy.