Publications [#280486] of David J. Brady
- McCain, ST; Gehm, ME; Wang, Y; Pitsianis, NP; Brady, DJ, Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom.,
Applied Spectroscopy, vol. 60 no. 6
pp. 663-671, ISSN 0003-7028 , [doi]
(last updated on 2019/11/12)
Coded aperture spectroscopy allows for sources of large étendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve r(2) > 0.98. Leave-one-out cross-validation demonstrates prediction errors of <15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves <12% error at this concentration.
Raman spectroscopy;Tissue;Optimization;Spectrometers;Regression analysis;Multiplexing;