Publications [#229634] of H. Frederik Nijhout
- Nijhout, HF, Size matters (but so does time), and it's OK to be different.,
Developmental Cell, vol. 15 no. 4
pp. 491-492 , [doi]
(last updated on 2019/10/14)
In this issue of Developmental Cell, Layalle et al. reveal new insights into how nutrition controls body size in Drosophila. Nutrition specifically affects the activity of target of rapamycin (TOR) in the prothoracic gland. Under low-nutrition conditions, TOR suppresses ecdysone secretion--which otherwise terminates larval development--thereby prolonging growth and allowing larvae to still attain a near-normal body size.