Math @ Duke
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Publications [#323711] of Amanda Randles
Papers Published
- Gounley, J; Chaudhury, R; Vardhan, M; Driscoll, M; Pathangey, G; Winarta, K; Ryan, J; Frakes, D; Randles, A, Does the degree of coarctation of the aorta influence wall shear stress focal
heterogeneity?, vol. 2016 no. 2016
(August, 2016),
pp. 3429-3432, IEEE, ISBN 9781457702204 [doi]
(last updated on 2024/03/28)
Abstract: The development of atherosclerosis in the aorta is
associated with low and oscillatory wall shear stress for normal
patients. Moreover, localized differences in wall shear stress
heterogeneity have been correlated with the presence of complex
plaques in the descending aorta. While it is known that coarctation
of the aorta can influence indices of wall shear stress,
it is unclear how the degree of narrowing influences resulting
patterns. We hypothesized that the degree of coarctation would
have a strong influence on focal heterogeneity of wall shear
stress. To test this hypothesis, we modeled the fluid dynamics
in a patient-specific aorta with varied degrees of coarctation.
We first validated a massively parallel computational model
against experimental results for the patient geometry and
then evaluated local shear stress patterns for a range of
degrees of coarctation. Wall shear stress patterns at two cross
sectional slices prone to develop atherosclerotic plaques were
evaluated. Levels at different focal regions were compared to the
conventional measure of average circumferential shear stress
to enable localized quantification of coarctation-induced shear
stress alteration. We find that the coarctation degree causes
highly heterogeneous changes in wall shear stress.
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