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Publications [#257895] of David B. Dunson

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Papers Published

  1. Nyska, A; Lomnitski, L; Spalding, J; Dunson, DB; Goldsworthy, TL; Grossman, S; Bergman, M; Boorman, G, Topical and oral administration of the natural water-soluble antioxidant from spinach reduces the multiplicity of papillomas in the Tg.AC mouse model, Toxicology Letters, vol. 122 no. 1 (2001), pp. 33-44, ISSN 0378-4274 [doi]
    (last updated on 2017/12/15)

    Abstract:
    The Tg.AC mouse carrying the v-Ha-ras structural gene is a useful model for the study of chemical carcinogens, especially those acting via non-genotoxic mechanisms. This study evaluated the efficacy of the non-toxic, water-soluble antioxidant from spinach, natural antioxidant (NAO), in reducing skin papilloma induction in female hemizygous Tg.AC mice treated dermally five times over 2.5 weeks with 2.5 μg 12-O-tetradecanoylphorbol-13-acetate (TPA). The TPA-only group was considered as a control; the other two groups received, additionally, NAO topically (2 mg) or orally (100 mg/kg), 5 days/week for 5 weeks. Papilloma counts made macroscopically during the clinical observations showed a significant decrease in multiplicity (P < 0.01) in the NAO topically treated group. According to histological criteria, papilloma multiplicity were lower in both topical-NAO and oral-NAO groups, but significantly so only in the oral-NAO mice (P < 0.01). The beneficial effect of NAO in the Tg.AC mouse is reported. © 2001 Elsevier Science Ireland Ltd.

 

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