Publications [#346389] of Anita T. Layton

Papers Published

1. Sgouralis, I; Layton, AT, Modeling Blood Flow and Oxygenation in a Diabetic Rat Kidney, vol. 8 (January, 2017), pp. 101-113 [doi]
   (last updated on 2020/07/05)

   Abstract:
   © 2017, The Author(s) and the Association for Women in Mathematics. We use a highly detailed mathematical model of renal hemodynamics and solute transport to simulate medullary oxygenation in the kidney of a diabetic rat. Model simulations suggest that alterations in renal hemodynamics, which include diminished vasoconstrictive response of the afferent arteriole as a major factor, lead to glomerular hyperfiltration in diabetes. The resulting higher filtered Na+ load increases the reabsorptive work of the nephron, but by itself does not significantly elevate medullary oxygen consumption. The key explanation for diabetes-related medullary hypoxia may be impaired renal metabolism. Tubular transport efficiency is known to be reduced in diabetes, leading to increased medullary oxygen consumption, despite relatively unchanged active Na+ transport. The model predicts that interstitial fluid oxygen tension of the inner stripe, which is a particularly oxygen-poor region of the medulla, decreases by 18.6% in a diabetic kidney.