Publications [#381576] of Anru Zhang

Papers Published

1. Shi, P; Martino, C; Han, R; Janssen, S; Buck, G; Serrano, M; Owzar, K; Knight, R; Shenhav, L; Zhang, AR, TEMPTED: time-informed dimensionality reduction for longitudinal microbiome studies., Genome Biol, vol. 25 no. 1 (December, 2024), pp. 317 [doi]
   (last updated on 2026/02/08)

   Abstract:
   Longitudinal studies are crucial for understanding complex microbiome dynamics and their link to health. We introduce TEMPoral TEnsor Decomposition (TEMPTED), a time-informed dimensionality reduction method for high-dimensional longitudinal data that treats time as a continuous variable, effectively characterizing temporal information and handling varying temporal sampling. TEMPTED captures key microbial dynamics, facilitates beta-diversity analysis, and enhances reproducibility by transferring learned representations to new data. In simulations, it achieves 90% accuracy in phenotype classification, significantly outperforming existing methods. In real data, TEMPTED identifies vaginal microbial markers linked to term and preterm births, demonstrating robust performance across datasets and sequencing platforms.