Publications [#386474] of Jichun Xie

Papers Published

1. Qu, Y; Ji, B; Dong, R; Gu, L; Chan, C; Xie, J; Glass, C; Wang, X-F; Nixon, AB; Ji, Z, Single-cell and spatial detection of senescent cells using DeepScence., Cell Genom, vol. 5 no. 12 (December, 2025), pp. 101035 [doi]
   (last updated on 2026/01/16)

   Abstract:
   Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence is based on CoreScence, a senescence-associated gene set we curated that incorporates information from multiple published gene sets. We demonstrate that DeepScence can accurately identify senescent cells in single-cell gene expression data collected both in vitro and in vivo, as well as in spatial transcriptomics data generated by different platforms, substantially outperforming existing methods.