Math @ Duke
|
Publications [#244094] of Michael C. Reed
Papers Published
- Reed, MC; Blum, J; Washington, T; Conn, JM, A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH,
Theoretical Biology and Medical Modeling, vol. 1 no. 9
(2004),
pp. 1-17 [doi]
(last updated on 2024/07/16)
Abstract: In a previous study, a model was developed
to investigate the release of luteinizing
hormone (LH) from pituitary cells
in response to a short pulse of
gonadotropin-releasing
hormone (GnRH). The model included: binding
of GnRH to
its receptor (R), dimerization and
internalization of the
hormone receptor complex, interaction with a
G protein,
production of inositol 1,4,5-trisphosphate (IP3),
release of calcium from the endoplasmic
reticulum (ER),
entrance of calcium into the cytosol via
voltage gated membrane channels,
pumping of calcium out of the cytosol via
membrane and ER pumps, and release
of LH. The extended model, presented in this
paper, also
includes the following physiologically
important phenomena:
desensitization of calcium channels;
internalization of the
dimerized receptors and recycling of some of
the internalized receptors;
an increase in Gq concentration near the
plasma membrane in response
to receptor dimerization; and basal rates of
synthesis and degradation of
the receptors. With suitable choices of the
parameters, good
agreement with a variety of experimental data
of the LH release pattern
in response to pulses of various durations,
repetition rates,
and concentrations of GnRH were obtained. The
mathematical model allows
us to assess the effects of internalization
and desensitization on the
shapes and time courses of LH response curves.
|
|
dept@math.duke.edu
ph: 919.660.2800
fax: 919.660.2821
| |
Mathematics Department
Duke University, Box 90320
Durham, NC 27708-0320
|
|