Publications [#243533] of Richard T. Durrett

Papers Published

1. De, A; Durrett, R, Spatial structure of the human population contributes to the slow decay of linkage diseqeuilibrium and shifts the site frequency spectrum, Genetics, vol. 176 no. 2 (2007), pp. 969-981, ISSN 0016-6731
   (last updated on 2024/04/24)

   Abstract:
   The symmetric island model with D demes and equal migration rates is often chosen for the investigation of the consequences of population subdivision. Here we show that a stepping-stone model has a more pronounced effect on the genealogy of a sample. For samples from a small geographical region commonly used in genetic studies of humans and Drosophila, there is a shift of the frequency spectrum that decreases the number of low-frequency-derived alleles and skews the distribution of statistics of Tajima, Fu and Li, and Fay and Wu. Stepping-stone spatial structure also changes the two-locus sampling distribution and increases both linkage disequilibrium and the probability that two sites are perfectly correlated. This may cause a false prediction of cold spots of recombination and may confuse haplotype tests that compute probabilities on the basis of a homogeneously mixing population. Copyright © 2007 by the Genetics Society of America.