Math @ Duke

Publications [#287327] of Harold Layton
Papers Published
 Layton, AT; Moore, LC; Layton, HE, Multistable dynamics mediated by tubuloglomerular feedback in a model of coupled nephrons.,
Bulletin of Mathematical Biology, vol. 71 no. 3
(April, 2009),
pp. 515555 [19205808], [doi]
(last updated on 2018/12/19)
Abstract: To help elucidate the causes of irregular tubular flow oscillations found in the nephrons of spontaneously hypertensive rats (SHR), we have conducted a bifurcation analysis of a mathematical model of two nephrons that are coupled through their tubuloglomerular feedback (TGF) systems. This analysis was motivated by a previous modeling study which predicts that NaCl backleak from a nephron's thick ascending limb permits multiple stable oscillatory states that are mediated by TGF (Layton et al. in Am. J. Physiol. Renal Physiol. 291:F79F97, 2006); that prediction served as the basis for a comprehensive, multifaceted hypothesis for the emergence of irregular flow oscillations in SHR. However, in that study, we used a characteristic equation obtained via linearization from a singlenephron model, in conjunction with numerical solutions of the full, nonlinear model equations for two and three coupled nephrons. In the present study, we have derived a characteristic equation for a model of any finite number of mutually coupled nephrons having NaCl backleak. Analysis of that characteristic equation for the case of two coupled nephrons has revealed a number of parameter regions having the potential for differing stable dynamic states. Numerical solutions of the full equations for two model nephrons exhibit a variety of behaviors in these regions. Some behaviors exhibit a degree of complexity that is consistent with our hypothesis for the emergence of irregular oscillations in SHR.


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