Math @ Duke

Publications [#243492] of Richard T. Durrett
Papers Published
 Durrett, RT; Chen, KY; Tanksley, SD, A simple formula useful for positional cloning,
Genetics, vol. 160 no. 1
(2002),
pp. 353355, ISSN 00166731
(last updated on 2018/03/20)
Abstract: We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments. The predictions of this formula agree well with the results from a number of published experiments in Arabidopsis.


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