Math @ Duke

Publications [#243533] of Richard T. Durrett
Papers Published
 De, A; Durrett, R, Spatial structure of the human population contributes to the slow decay of linkage diseqeuilibrium and shifts the site frequency spectrum,
Genetics, vol. 176 no. 2
(2007),
pp. 969981, ISSN 00166731 [doi]
(last updated on 2018/03/19)
Abstract: The symmetric island model with D demes and equal migration rates is often chosen for the investigation of the consequences of population subdivision. Here we show that a steppingstone model has a more pronounced effect on the genealogy of a sample. For samples from a small geographical region commonly used in genetic studies of humans and Drosophila, there is a shift of the frequency spectrum that decreases the number of lowfrequencyderived alleles and skews the distribution of statistics of Tajima, Fu and Li, and Fay and Wu. Steppingstone spatial structure also changes the twolocus sampling distribution and increases both linkage disequilibrium and the probability that two sites are perfectly correlated. This may cause a false prediction of cold spots of recombination and may confuse haplotype tests that compute probabilities on the basis of a homogeneously mixing population. Copyright © 2007 by the Genetics Society of America.


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