Math @ Duke

Publications [#243556] of Richard T. Durrett
Papers Published
 Durrett, R; Schmidt, D; Schweinsberg, J, A waiting time problem arising from the study of multistage carcinogenesis,
The annals of applied probability : an official journal of the Institute of Mathematical Statistics, vol. 19 no. 2
(2009),
pp. 676718, ISSN 10505164 [MR2521885 (2010f:60243)], [doi]
(last updated on 2017/12/11)
Abstract: We consider the population genetics problem: how long does it take before some member of the population has m specified mutations? The case m = 2 is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger m are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth. © Institute of Mathematical Statistics, 2009.


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