Publications [#354949] of Thomas P. Witelski

Papers Published

1. Zhu, H; Zhang, P; Zhong, Z; Xia, J; Rich, J; Mai, J; Su, X; Tian, Z; Bachman, H; Rufo, J; Gu, Y; Kang, P; Chakrabarty, K; Witelski, TP; Huang, TJ, Acoustohydrodynamic tweezers via spatial arrangement of streaming vortices., Science advances, vol. 7 no. 2 (January, 2021), pp. eabc7885 [doi]
   (last updated on 2024/04/23)

   Abstract:
   Acoustics-based tweezers provide a unique toolset for contactless, label-free, and precise manipulation of bioparticles and bioanalytes. Most acoustic tweezers rely on acoustic radiation forces; however, the accompanying acoustic streaming often generates unpredictable effects due to its nonlinear nature and high sensitivity to the three-dimensional boundary conditions. Here, we demonstrate acoustohydrodynamic tweezers, which generate stable, symmetric pairs of vortices to create hydrodynamic traps for object manipulation. These stable vortices enable predictable control of a flow field, which translates into controlled motion of droplets or particles on the operating surface. We built a programmable droplet-handling platform to demonstrate the basic functions of planar-omnidirectional droplet transport, merging droplets, and in situ mixing via a sequential cascade of biochemical reactions. Our acoustohydrodynamic tweezers enables improved control of acoustic streaming and demonstrates a previously unidentified method for contact-free manipulation of bioanalytes and digitalized liquid handling based on a compact and scalable functional unit.