Research Interests for Redford B. Williams

Psychosocial precursors of medical illness and death, with particular emphasis on the role of the hostility complex (cynicism, anger, and aggression) and social support in the etiology and course of coronary heart disease; biological and neurobiological mechanisms whereby psychosocial influences on health are mediated; more basic studies of the psychophysiology of the autonomic nervous system and neuroendocrine system; the role of genetic variation in behavioral, emotional, and biological responses to stress; psychiatric comorbidity in medical disorders; cross-cultural studies of psychosocial factors in illness, with collaborations currently with investigators in Japan and the USSR.

Keywords:

Achievement, Activities of Daily Living, Adaptation, Psychological, Adenosine Diphosphate, Adiposity, Adolescent, Adolescent Development, Adolescent Psychology, Adrenergic Agonists, Adrenergic beta-Antagonists, Adrenergic Fibers, Adrenocorticotropic Hormone, Adult, Affect, African Americans, African Continental Ancestry Group, Age Distribution, Age Factors, Aged, Aged, 80 and over, Aging, Alcohol Drinking, Alleles, Alzheimer Disease, Amino Acid Sequence, Amino Acid Substitution, Analysis of Variance, Anemia, Sickle Cell, Anger, Angina Pectoris, Angioplasty, Balloon, Coronary, Animals, Anti-Anxiety Agents, Antigens, CD11a, Antigens, CD11b, Antigens, CD11c, Antigens, CD18, Antisocial Personality Disorder, Anxiety, Anxiety Disorders, Apolipoproteins E, Arginine, Arousal, Aryl Hydrocarbon Hydroxylases, Atropine, Attention, Attention Deficit Disorder with Hyperactivity, Attitude, Attitude to Health, Authoritarianism, Automobile Driving, Autonomic Nervous System, Base Sequence, Beer, Behavior, Behavior Therapy, Benzodiazepines, beta-Endorphin, Biofeedback, Psychology, Biological Markers, Biological Transport, Bipolar Disorder, Blood Glucose, Blood Platelets, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Body Mass Index, Body Weights and Measures, Brain, Brain-Derived Neurotrophic Factor, C-Reactive Protein, Caffeine, Cardiac Catheterization, Cardiac Output, Cardiovascular Diseases, Cardiovascular Physiological Phenomena, Cardiovascular System, Caregivers, Carrier Proteins, Case-Control Studies, Catecholamines, Cause of Death, Cells, Cultured, Central Nervous System, Chemokine CCL2, Chemokine CXCL1, Chemokines, Chemokines, CXC, Chemotactic Factors, Chi-Square Distribution, Child, Cholesterol, Cholesterol, HDL, Cholesterol, LDL, Chromatography, High Pressure Liquid, Chronic Disease, Circadian Rhythm, Citalopram, Clergy, Clinical Trials as Topic, Cluster Analysis, Cognition, Cohort Studies, Cold Temperature, Collagen, Combined Modality Therapy, Community-Institutional Relations, Comorbidity, Confidence Intervals, Conflict (Psychology), Continental Population Groups, Coronary Angiography, Coronary Artery Bypass, Coronary Artery Disease, Coronary Circulation, Coronary Disease, Coronary heart disease, Cost of Illness, Crime, Cross-Sectional Studies, Culture, Cyclic AMP, Cysteine, Cytokines, Cytotoxicity, Immunologic, Decision Making, Defense Mechanisms, Dementia, Demography, Denmark, Depression, Depressive Disorder, Depressive Disorder, Major, Diabetes Mellitus, Diabetes Mellitus, Type 2, Diastole, Diazepam, Diet, Dietary Fats, Disability Evaluation, Disease Progression, DNA, DNA Mutational Analysis, DNA Primers, Dopamine beta-Hydroxylase, Dose-Response Relationship, Drug, Double-Blind Method, Drug Therapy, Drug Tolerance, Echocardiography, Educational Status, Ego, Electrocardiography, Emergency Service, Hospital, Emotions, Employment, Endophenotypes, Endorphins, Environment, Epinephrine, Ethnic Groups, European Continental Ancestry Group, Exercise, Exercise Test, Exploratory Behavior, Extraversion (Psychology), Factor Analysis, Statistical, Family, Family Characteristics, Fasting, Fathers, Female, Finland, Flow Cytometry, Follow-Up Studies, Food Preferences, Forearm, Forecasting, Gene Expression, Gene Frequency, Gene-Environment Interaction, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Testing, Genetic Variation, Genome-Wide Association Study, Genotype, Glucose Intolerance, Glucose Tolerance Test, Growth Hormone, Health Behavior, Health Promotion, Health Status, Health Status Disparities, Health Status Indicators, Health Surveys, Heart, Heart Diseases, Heart Rate, Hemodynamics, Hemoglobin A, Glycosylated, Hispanic Americans, Histidine, History, 20th Century, Holistic Health, Hormones, Hospitalization, Hostility, Humans, Hydrocortisone, Hydroxyindoleacetic Acid, Hyperlipidemias, Hypertension, Hypochondriasis, Hypothalamo-Hypophyseal System, Hypothalamus, Immunity, Cellular, Impulsive Behavior, Income, Individuality, Inflammation, Infusions, Intravenous, Insulin, Insulin Resistance, Interleukin-1, Interleukin-6, Internal-External Control, Interpersonal Relations, Intervention Studies, Interview, Psychological, Irritable Mood, Isoproterenol, Job Satisfaction, Kinetics, Least-Squares Analysis, Length of Stay, Leukocytes, Mononuclear, Life Change Events, Life Style, Linear Models, Lipids, Lipopolysaccharides, Lipoproteins, HDL, Lipoproteins, LDL, Logistic Models, Longevity, Longitudinal Studies, Macrophage Activation, Macrophages, Male, Marital Status, Marriage, Mathematics, Membrane Glycoproteins, Membrane Transport Proteins, Mental Health, Mental Recall, Metabolic syndrome, Metabolic Syndrome X, Metabolism, Methionine, Mice, Mice, Inbred C57BL, Middle Aged, Military Personnel, Mind-Body Relations, Metaphysical, Minisatellite Repeats, MMPI, Models, Psychological, Models, Statistical, Molecular Sequence Data, Monoamine Oxidase, Monocytes, Motivation, Motor Activity, Multicenter Studies as Topic, Multivariate Analysis, Muscle, Smooth, Vascular, Muscles, Mutation, Myocardial Infarction, Myocardial Ischemia, Naloxone, Neoplasms, Nerve Tissue Proteins, Neural Inhibition, Neurotic Disorders, Nitrates, Nitric Oxide, Norepinephrine, North Carolina, Obesity, Obesity, Abdominal, Occupational Health, Occupations, Odds Ratio, Organizational Case Studies, Outcome and Process Assessment (Health Care), Oxidation-Reduction, Oxygen, Panic Disorder, Paranoid Personality Disorder, Parasympathetic Nervous System, Parenting, Parents, Paroxetine, Patient Care Team, Patient Compliance, Patient Discharge, Patient Selection, PC12 Cells, Permissiveness, Personality, Personality Assessment, Personality Development, Personality Disorders, Personality Inventory, Personality Tests, Phenotype, Physical Education and Training, Physical Exertion, Physical Fitness, Physician-Patient Relations, Pituitary-Adrenal System, Plasminogen Activators, Platelet Aggregation, Platelet Function Tests, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Posture, Predictive Value of Tests, Prejudice, Premedication, Prevalence, Problem Solving, Prognosis, Prolactin, Promoter Regions, Genetic, Proportional Hazards Models, Propranolol, Prospective Studies, Protestantism, Psychiatric Status Rating Scales, Psychology, Psychometrics, Psychophysiologic Disorders, Psychophysiology, Psychosocial Deprivation, Psychotherapy, Psychotropic Drugs, Quality of Life, Questionnaires, Race, Race Relations, Radioimmunoassay, Randomized Controlled Trial, Rats, Receptor, Serotonin, 5-HT2C, Receptors, Adrenergic, beta, Receptors, Dopamine D2, Receptors, Dopamine D4, Receptors, Opioid, Recovery of Function, Reference Values, Regional Blood Flow, Regression Analysis, Religion and Medicine, Reproducibility of Results, Research Design, Research Report, Residence Characteristics, Residential Facilities, Retrospective Studies, Risk, Risk Assessment, Risk Factors, RNA, Messenger, Saliva, Selection Bias, Self Concept, Self Report, Self-Assessment, Self-Help Groups, Sensitivity and Specificity, Serine, Serotonin, Serotonin Plasma Membrane Transport Proteins, Serotonin Uptake Inhibitors, Severity of Illness Index, Sex, Sex Characteristics, Sex Distribution, Sex Factors, Sick Role, Sickness Impact Profile, Single Parent, Sleep, Sleep Disorders, Smoking, Smoking Cessation, Social Behavior, Social Class, Social Environment, Social Isolation, Social Perception, Social Support, Socioeconomic Factors, Socioeconomic status, Somatoform Disorders, Speech, Spouses, Statistics as Topic, Stress Disorders, Post-Traumatic, Stress, Psychological, Stroke Volume, Students, Survival Analysis, Survival Rate, Sympathetic Nervous System, Synaptic Transmission, Systole, Tandem Repeat Sequences, Task Performance and Analysis, Teaching, Testosterone, Thematic Apperception Test, Time Factors, Treatment Outcome, Triglycerides, Tryptophan, Tryptophan Hydroxylase, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Type A Personality, Unemployment, United States, Universities, Vagus Nerve, Valine, Vascular Resistance, Vasomotor System, Ventricular Function, Left, Veterans, Video Recording, Waist Circumference, Weight Gain, Wine, Women, Working, Workload, Young Adult

Representative Publications   (search)

1. Williams, R.B. Neurobiology, cellular and molecular biology, and psychosomatic medicine. PSYCHOSOMATIC MEDICINE, 56: 308-315, 1994. .
2. Williams, R.B., Barefoot, J.C., Califf, R.M., Haney, T.L., Saunders, W.B., Pryor, D.B., Hlatky, M.A., Siegler, I.C., & Mark, D.B. Prognostic importance of social and economic resources among medically treated patients with angiographically documented coronary artery disease. JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 267: 520-524, 1992. .
3. Williams, R.B. Psychological factors in coronary artery disease: Epidemiologic evidence. CIRCULATION, 76: 117-123, 1987. .
4. Williams, R.B., Lane, J.D., Kuhn, C.M., Melosh, W., White, A.D. & Schanberg, S.M. Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks. SCIENCE, 218: 483-485, 1982. .
5. Williams, R.B., Haney, T.L., Blumenthal, J.A., & Kong, Y. Type A behavior, hostility, and coronary atherosclerosis. PSYCHOSOMATIC MEDICINE, 42(6): 539-549, 1980. .