Psychology and Neuroscience Faculty Database
Psychology and Neuroscience
Arts & Sciences
Duke University

 HOME > Arts & Sciences > pn > Faculty    Search Help Login pdf version printable version 

Publications [#254543] of Christina L. Williams

search PubMed.

Journal Articles

  1. Matsubara, E; Bryant-Thomas, T; Pacheco Quinto, J; Henry, TL; Poeggeler, B; Herbert, D; Cruz-Sanchez, F; Chyan, Y-J; Smith, MA; Perry, G; Shoji, M; Abe, K; Leone, A; Grundke-Ikbal, I; Wilson, GL; Ghiso, J; Williams, C; Refolo, LM; Pappolla, MA; Chain, DG; Neria, E (2003). Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.. Journal of Neurochemistry, 85(5), 1101-1108. [doi]
    (last updated on 2020/09/24)

    Abstract:
    Increased levels of a 40-42 amino-acid peptide called the amyloid beta protein (A beta) and evidence of oxidative damage are early neuropathological markers of Alzheimer's disease (AD). Previous investigations have demonstrated that melatonin is decreased during the aging process and that patients with AD have more profound reductions of this hormone. It has also been recently shown that melatonin protects neuronal cells from A beta-mediated oxidative damage and inhibits the formation of amyloid fibrils in vitro. However, a direct relationship between melatonin and the biochemical pathology of AD had not been demonstrated. We used a transgenic mouse model of Alzheimer's amyloidosis and monitored over time the effects of administering melatonin on brain levels of A beta, abnormal protein nitration, and survival of the mice. We report here that administration of melatonin partially inhibited the expected time-dependent elevation of beta-amyloid, reduced abnormal nitration of proteins, and increased survival in the treated transgenic mice. These findings may bear relevance to the pathogenesis and therapy of AD.


Duke University * Arts & Sciences * Faculty * Staff * Grad * Postdocs * Reload * Login