Research Interests for Warren H. Meck

Research interests include the neuroanatomical and neuropharmacological basis of timing and time perception in the seconds-to-minutes range. This work relates to the striatal beat-frequency theory of interval timing as well as mode-control models of temporal integration and attentional time-sharing in humans and other animals. Current work focuses on the use of genomic and ensemble-recording techniques designed to identify the basic properties of interval timing and decision making in cortical-striatal circuits. Additional work utilizes neuroimaging techniques (e.g., EEG & fMRI) to examine temporal processing deficits in selected clinical populations. Another major focus for our research uses animal models to study developmental periods of dietary choline sensitivity that provide an ontogenetic mechanism for regulating memory capacity and precision in adulthood. This work includes the study of prenatal choline effects on sleep-dependent memory consolidation processes in adult rats and mice as well as inoculation against age-related impairments in spatial and temporal cognition.

Keywords:

3,4-Dihydroxyphenylacetic Acid, acetylcholine, Acetylcholine, Acetylcholinesterase, Acoustic Stimulation, Action Potentials, Administration, Cutaneous, Adolescent, Adult, Age Factors, Aged, Aging, Alcoholic Intoxication, Algorithms, Amphetamine, Amphetamine-Related Disorders, Amygdala, Analysis of Variance, Animals, Animals, Newborn, Antipsychotic Agents, Appetitive Behavior, Arginine Vasopressin, Association Learning, Atropine, Atropine Derivatives, Attention, Attention Deficit Disorder with Hyperactivity, Auditory Perception, Autistic Disorder, Basal Ganglia, Basal Ganglia Diseases, Basal Nucleus of Meynert, Behavior, Behavior, Animal, Biofeedback, Psychology, Biological Clocks, Biological Evolution, Brain, Brain Chemistry, Brain Mapping, Brain-Derived Neurotrophic Factor, Bromodeoxyuridine, Carbachol, Case-Control Studies, Cell Proliferation, Central Nervous System Stimulants, Cerebral Cortex, Child, Choice Behavior, choline, Choline, Choline Deficiency, Choline O-Acetyltransferase, Cholinergic Fibers, Chromatography, High Pressure Liquid, Chronobiology Phenomena, circadian and interval clocks, Circadian Rhythm, Clozapine, Cocaine, Cognition, Cognition Disorders, Columbidae, Computer Simulation, Computer Systems, Concept Formation, Conditioning (Psychology), Conditioning, Classical, Conditioning, Operant, Corpus Striatum, Cortical Synchronization, cortico-striatal circuits, Counting, Cues, Cyclic AMP Response Element-Binding Protein, Data Interpretation, Statistical, Decision Making, Denervation, Dentate Gyrus, development, Diagnostic Imaging, Dietary Supplements, Differential Threshold, Discrimination (Psychology), Discrimination Learning, dopamine, Dopamine, Dopamine Agents, Dopamine Agonists, Dopamine Antagonists, Dopamine Plasma Membrane Transport Proteins, Dopamine Uptake Inhibitors, Dose-Response Relationship, Drug, Double-Blind Method, Down-Regulation, Drug Administration Schedule, Drug Synergism, Electric Stimulation, Electrochemistry, Electroencephalography, Electromyography, Electrophysiology, Electroshock, Embryonic and Fetal Development, Emotions, Energy Metabolism, Enzyme Inhibitors, Epigenetics, Epilepsy, Estradiol, Ethanol, Euphoria, Evoked Potentials, Evoked Potentials, Auditory, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Extinction, Psychological, Family Health, Fear, Feedback, Feedback, Psychological, Feeding Behavior, Female, Fetus, Field Dependence-Independence, Frontal Lobe, Functional Laterality, GABA, GABA Agonists, Gene Deletion, Gene Expression, Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic, Generalization (Psychology), Genes, RAG-1, Genetic Predisposition to Disease, Gestational Age, Glutamic Acid, Gonadal Steroid Hormones, Habituation, Psychophysiologic, Haloperidol, Hippocampus, Humans, Hypertrophy, Hypothalamus, Posterior, Image Processing, Computer-Assisted, Imprinting (Psychology), Impulsive Behavior, Individuality, Infant, Information Theory, Injections, Insulin-Like Growth Factor I, Interpersonal Relations, Judgment, Ketamine, Kinetics, Learning, learning & memory, Limbic System, Long-Term Potentiation, Magnetic Resonance Imaging, Male, MAP Kinase Signaling System, Maternal-Fetal Exchange, Maze Learning, Memory, Memory Disorders, Memory, Short-Term, Mental Disorders, Mental Processes, Mental Recall, Methamphetamine, Mice, Mice, Inbred C57BL, Mice, Knockout, Middle Aged, Mitogen-Activated Protein Kinases, Models, Biological, Models, Neurological, Models, Psychological, Models, Theoretical, Mood Disorders, Motion Perception, Motivation, Motor Activity, Movement, Muridae, Muscarinic Agonists, Muscimol, Music, N-Methylaspartate, Neostigmine, Neostriatum, Nerve Fibers, Nerve Net, Neural Pathways, Neurobiology, Neurogenesis, Neuronal Plasticity, Neurons, Neuropeptides, Neurophysiology, Neuropsychological Tests, Neuropsychology, Neurotic Disorders, Neurotoxins, Nicotine, Nicotinic Agonists, Nootropic Agents, Norepinephrine, Normal Distribution, Nutrition, Nutritional Physiological Phenomena, Obsessive-Compulsive Disorder, Organ Specificity, Orientation, Ovary, Oxidopamine, Oxygen, Oxytocin, Parasympathetic Nervous System, Parkinson Disease, Peptide Fragments, Perception, Perceptual Distortion, Perinatal Care, Phosphorylation, Photic Stimulation, Photoperiod, Physostigmine, Potassium, Practice (Psychology), Prefrontal Cortex, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Prenatal Nutritional Physiological Phenomena, Probability, Probability Learning, Problem Solving, Prognosis, Prosencephalon, Protein Processing, Post-Translational, Protein Synthesis Inhibitors, Proteins, Psychiatric Status Rating Scales, Psychoacoustics, Psychological Theory, Psychomotor Performance, Psychophysics, Pyrrolidonecarboxylic Acid, Questionnaires, Quinpirole, Quinuclidinyl Benzilate, Raclopride, Random Allocation, Rats, Rats, Inbred Strains, Rats, Long-Evans, Rats, Sprague-Dawley, Reaction Time, Receptor, Nerve Growth Factor, Receptors, Cholinergic, Receptors, Dopamine, Receptors, Dopamine D2, Receptors, Muscarinic, Receptors, N-Methyl-D-Aspartate, Receptors, Nerve Growth Factor, Recognition (Psychology), Reference Values, Reinforcement (Psychology), Reinforcement Schedule, Reproducibility of Results, Retention (Psychology), Reversal Learning, Reward, Risk Factors, Schizophrenia, Schizophrenic Psychology, Sensory Thresholds, Septal Nuclei, Septum Pellucidum, Serotonin, Serotonin Antagonists, Sex Characteristics, Sex differences, Sex Differentiation, Sexual Maturation, Signal Detection, Psychological, Sleep, Smoking, Social Environment, Sodium, Sodium Chloride, Dietary, Space Perception, Spatial Behavior, Species Specificity, Sucrose, Synapses, Synaptic Transmission, Systems Biology, Systems Integration, Task Performance and Analysis, Taste, Temporal Lobe, Testis, Testosterone, Time, Time Factors, Time Perception, Touch, Toxicity Tests, Transcription Factors, Transfer (Psychology), Tyrosine, Vasopressins, Vestibular Nuclei, Videotape Recording, Visual Acuity, Visual Perception, Water, Young Adult

Representative Publications   (search)

1. Buhusi, CV; Meck, WH, Relative time sharing: new findings and an extension of the resource allocation model of temporal processing., Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 364 no. 1525 (July, 2009), pp. 1875-1885 [19487190], [doi] [abs].
2. Buhusi, CV; Meck, WH, Relativity theory and time perception: single or multiple clocks?, Plos One, vol. 4 no. 7 (July, 2009), pp. e6268 [19623247], [doi] [abs].
3. Cheng, R-K, Neurophysiological Mechanisms of Sleep-Dependent Memory Consolidation and Its Facilitation by Prenatal Choline Supplementation, The Chinese Journal of Physiology, vol. 52 no. 4 (August, 2009), pp. 223-235, Medknow [Gateway.cgi], [doi].
4. Fortin, C; Fairhurst, S; Malapani, C; Morin, C; Towey, J; Meck, WH, Expectancy in humans in multisecond peak-interval timing with gaps., Attention, Perception & Psychophysics, vol. 71 no. 4 (May, 2009), pp. 789-802 [19429959], [doi] [abs].
5. MacDonald, CJ; Meck, WH; Simon, SA; Nicolelis, MAL, Taste-guided decisions differentially engage neuronal ensembles across gustatory cortices., Journal of Neuroscience, vol. 29 no. 36 (September, 2009), pp. 11271-11282 [19741134], [doi] [abs].
6. Brannon, EM; Libertus, ME; Meck, WH; Woldorff, MG, Electrophysiological measures of time processing in infant and adult brains: Weber's Law holds., Journal of Cognitive Neuroscience, vol. 20 no. 2 (February, 2008), pp. 193-203 [18275328], [doi] [abs].
7. Cheng, R-K; Williams, CL; Meck, WH, Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation., Brain Research, vol. 1237 (October, 2008), pp. 176-194 [18793620], [doi] [abs].
8. Meck, WH; Penney, TB; Pouthas, V, Cortico-striatal representation of time in animals and humans., Current Opinion in Neurobiology, vol. 18 no. 2 (April, 2008), pp. 145-152 [18708142], [doi] [abs].
9. Meck, WH; Williams, CL; Cermak, JM; Blusztajn, JK, Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia., Frontiers in Integrative Neuroscience, vol. 1 (January, 2007), pp. 7 (doi:10.3389/neuro.07.007.2007.) [18958235], [doi] [abs].
10. Penney, TB; Gibbon, J; Meck, WH, Categorical scaling of duration bisection in pigeons (Columba livia), mice (Mus musculus), and humans (homo sapiens), Psychological Science, vol. 19 no. 11 (2008), pp. 1102-1108 [19076481], [doi] [abs].
11. Droit-Volet, S; Meck, WH, How emotions colour our perception of time., Trends in Cognitive Sciences, vol. 11 no. 12 (December, 2007), pp. 504-513 [18023604], [doi] [abs].
12. Buhusi, CV; Meck, WH, What makes us tick? Functional and neural mechanisms of interval timing., Nature Reviews. Neuroscience, vol. 6 no. 10 (October, 2005), pp. 755-765 [16163383], [doi] [abs].