Dr. Yuan's research interests include drug and gene delivery, mechanisms of molecular transport in cells and tissues, and tumor pathophysiology.

Cure of cancer through chemotherapy requires drug molecules to reach all tumor cells at an adequately high concentration. At present, such a requirement cannot be satisfied in most patients. This is because (a) amount of drugs that can be administered into patients is limited by normal tissue tolerance and (b) drug distribution and cellular response to drugs in tumors are heterogeneous. Therefore, cells in regions with drug concentration below the therapeutic level will cause tumor recurrence and they may also develop resistance to future treatment.

The goal of our research is two-fold. One is to improve delivery of therapeutic agents in solid tumors; and the second is to understand mechanisms of drug resistance in tumors caused by intrinsic cellular heterogeneity and physiological barriers. These studies may provide useful information on how to improve clinical treatment of cancer based on currently available drugs or molecular medicines in the future.

Research projects in our lab include quantification of transport parameters, delivery of drugs encapsulated in temperature sensitive liposomes, physical interventions of drugs, electric field-mediated gene delivery, mathematical modeling of drug and gene delivery.

Contact Info:

Office Location:	1385, Fciemas, Duke Univers
Office Phone:	(919) 660-5411
Email Address:
Web Page:

Education:

PhD, The City University of New York, 1990

MS, Peking University, 1985

BS, Peking University, 1983

Research Interests:

Dr. Yuan's research interests include drug and gene delivery, mechanisms of molecular transport in cells and tissues, and tumor pathophysiology.

Specialties:

Drug Delivery
Biological Transport
Cancer diagnostics and therapy

Awards, Honors, and Distinctions

Fellow, American Institute for Medical and Biological Engineering, 2006
NSF Early CAREER Award, National Science Foundation, 2000

• BME 577.01, DRUG DELIVERY Synopsis

  Hudson 212, MW 03:05 PM-04:20 PM

Representative Publications   (More Publications)

1. Wang, Y. and Yuan, F., Delivery of viral vectors to tumor cells: extracellular transport, systemic distribution, and strategies for improvement, Ann. Biomed. Eng. (USA), vol. 34 no. 1 (2006), pp. 114 - 27 [s10439-005-9007-2]  [abs].