Papers Published

1. Zhao, Y; Chu, KK; Eldridge, WJ; Jelly, ET; Crose, M; Wax, A, Real-time speckle reduction in optical coherence tomography using the dual window method, Biomedical Optics Express, vol. 9 no. 2 (2018), pp. 616-622, Optical Society of America [doi] .
   (last updated on 2023/06/01)

   Abstract:
   Speckle is an intrinsic noise of interferometric signals which reduces contrast and degrades the quality of optical coherence tomography (OCT) images. Here, we present a frequency compounding speckle reduction technique using the dual window (DW) method. Using the DW method, speckle noise is reduced without the need to acquire multiple frames. A ~25% improvement in the contrast-to-noise ratio (CNR) was achieved using the DW speckle reduction method with only minimal loss (~17%) in axial resolution. We also demonstrate that real-time speckle reduction can be achieved at a B-scan rate of ~21 frames per second using a graphic processing unit (GPU). The DW speckle reduction technique can work on any existing OCT instrument without further system modification or extra components. This makes it applicable both in real-time imaging systems and during post-processing.