Papers Published

1. Backman, V; Gopal, V; Kalashnikov, M; Badizadegan, K; Gurjar, R; Wax, A; Georgakoudi, I; Mueller, M; Boone, CW; Dasari, RR; Feld, MS, Measuring cellular structure at submicrometer scale with light scattering spectroscopy, Ieee Journal of Selected Topics in Quantum Electronics, vol. 7 no. 6 (November, 2001), pp. 887-893, Institute of Electrical and Electronics Engineers (IEEE) [doi] .
   (last updated on 2023/06/01)

   Abstract:
   We present a novel instrument for imaging the angular distributions of light backscattered by biological cells and tissues. The intensities in different regions of the image are due to scatterers of different sizes. We exploit this to study scattering from particles smaller than the wavelength of light used, even when they are mixed with larger particles. We show that the scattering from subcellular structure in both normal and cancerous human cells is best fitted to inverse power-law distributions for the sizes of the scattering objects, and propose that the distribution of scattering objects may be different in normal versus cancerous cells.